期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 6, 页码 656-662出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.06.009
关键词
Endoderm; Pancreatic progenitors; Patterning; Diabetes; Stem cells
资金
- NCATS NIH HHS [UL1 TR000077] Funding Source: Medline
- NIDDK NIH HHS [R01 DK080823, R01 DK092456] Funding Source: Medline
- NIGMS NIH HHS [R01 GM072915] Funding Source: Medline
Recent advances in generating pancreatic cell types from human pluripotent stem cells has depended on our knowledge of the developmental processes that regulate pancreas development in vivo. The developmental events between gastrulation and formation of the embryonic pancreatic primordia are both rapid and dynamic and studies in frog, fish, chick, and mouse have identified the molecular basis of how the pancreas develops from multipotent endoderm progenitors. Here, we review the current status of our understanding of molecular mechanisms that control endoderm formation, endoderm patterning, and pancreas specification and highlight how these discoveries have allowed for the development of robust methods to generate pancreatic cells from human pluripotent stem cells. (C) 2012 Elsevier Ltd. All rights reserved.
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