期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 5, 页码 599-605出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.03.008
关键词
Adhesion; Extracellular matrix; Morphogenesis; Differentiation; Intracellular signaling; Stem cells
资金
- La Ligue Nationale Contre le Cancer (Equipe Labelisee)
- Agence Nationale de la Recherche [ANR-08-BLAN-0078-01]
- La Fondation pour la Recherche Medicale
- Agence Nationale de la Recherche (ANR) [ANR-08-BLAN-0078] Funding Source: Agence Nationale de la Recherche (ANR)
Integrins are ubiquitously expressed major cell surface receptors for extracellular matrix. Integrin interaction with their extracellular ligands triggers activation of the intracellular signaling pathways that control cell shape, motility, proliferation, survival, cell-type-specific gene expression. In this review, we summarize recent studies analyzing contribution of integrins to the control of the mammary morphogenesis and differentiation, function and maintenance of mammary stem and progenitor cells and resume the data from mouse models revealing the contribution of the integrin-mediated signaling to mammary tumorigenesis. (c) 2012 Elsevier Ltd. All rights reserved.
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