期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 22, 期 1, 页码 39-47出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.09.002
关键词
Endocytic recycling; ARF6; Cell motility; Cytokinesis; Cholesterol trafficking
资金
- American Cancer Society
- National Cancer Institute
- Leukemia and Lymphoma Society of America
- Walther Foundation
- Leda J. Sears Trust
A wide range of cellular activities depends upon endocytic recycling. ARF6, a small molecular weight GTPase, regulates the processes of endocytosis and endocytic recycling in concert with various effector molecules and other small GTPases. This review highlights three critical processes that involve ARF6-mediated endosomal membrane trafficking-cell motility, cytokinesis, and cholesterol homeostasis. In each case, the function of ARF6-mediated trafficking varies-including localization of specific protein and lipid cargo, regulation of bulk membrane movement, and modulation of intracellular signaling. As described in this review, mis-regulation of endocytic traffic can result in human disease when it compromises the cell's ability to regulate cell movement and invasion, cell division, and lipid homeostasis. (C) 2010 Elsevier Ltd. All rights reserved.
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