期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 22, 期 2, 页码 214-219出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.02.009
关键词
ATP release; Neuron-glia interactions; Axon volume; Intrinsic optical signals; Activity-dependent development; Synaptic-vesicle release; Neurotransmitter release; Axon swelling; Learning; Volume-activated anion channel; White matter
资金
- National Institutes of Child Health
- Human Development funds for intramural research
Studies on the release of ATP from neurons began with the earliest investigations of quantal neurotransmitter release in the 1950s, but in contrast to ATP release from other cells, studies of ATP release from neurons have been narrowly constrained to one mechanism, vesicular release. This is a consequence of the prominence of synaptic transmission in neuronal communication, but nonvesicular mechanisms for ATP release from neurons are likely to have a broader range of functions than synaptic release. Investigations of activity-dependent communication between axons and myelinating glia have stimulated a search for mechanisms that could release ATP from axons and other nonsynaptic regions in response to action potential firing. This has identified volume-activated anion channels as an important mechanism in activity-dependent ATP release from axons, and renewed interest in micromechanical changes in axons that accompany action potential firing. (C) 2011 Published by Elsevier Ltd.
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