期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 22, 期 5, 页码 521-529出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.06.003
关键词
NMDA receptor; GluN2B subunit; Post-translational modification; Chronic pain
资金
- EJLB-CIHR [CIHR66975, CIHR84256]
- Ministry of Education, Science and Technology in Korea through KOSEF [R32-10142]
- Fragile X Research Foundation of Canada
- National Research Foundation of Korea [R31-2011-000-10089-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
N-methyl-D-aspartate receptors (NMDA receptors) play critical roles in brain functions and diseases. The expression, trafficking, synaptic location and function of different NMDA receptor subtypes are not static, but regulated dynamically in a cell-specific and synapse-specific manner during physiological and pathological conditions. In this review, we will examine recent evidence on the post-translational modulation of NMDA receptors subunit, in particular GluN2B subunit, such as phosphorylation, palmitoylation, and ubiquitination. In parallel, we will overview the roles of these modifications of GluN2B-NMDA receptor subtype in physiological functions, such as learning and memory, and pathophysiological conditions, such as chronic pain, ischemia and neurodegenerative diseases. (C) 2011 Elsevier Ltd. All rights reserved.
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