期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 22, 期 6, 页码 551-558出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.03.008
关键词
Mitosis; Chromosome segregation; Cell cycle; Ubiquitination
资金
- National Institutes of Health
- Welch Foundation [I-1441]
- Howard Hughes Medical Institute
- CPRIT
Accurate chromosome segregation during mitosis is critical for maintaining genomic stability. The spindle checkpoint is a cellular surveillance system that ensures the fidelity of chromosome segregation. In response to sister chromatids not properly captured by spindle microtubules, the spindle checkpoint interferes with the functions of Cdc20, the mitotic activator of the anaphase-promoting complex or cyclosome (APC/C), thereby blocking APC/C-mediated degradation of securin and cyclin B to delay anaphase onset. This review summarizes the recent progress on the mechanisms by which checkpoint proteins inhibit APC/C, the conformational and enzymatic activation of checkpoint proteins, and the emerging roles of APC/C-dependent ubiquitination in checkpoint inactivation. (C) 2011 Elsevier Ltd. All rights reserved.
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