期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 21, 期 8, 页码 782-789出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.07.009
关键词
MicroRNA (miRNA); miRNA target gene; Gene duplication; Gene origin and evolution; Genetic drift
资金
- KTRDC
- KSEF [KSTC-144-401-08-029]
- USDA [2006-35301-17115, 2006-35100-17433]
- NSF [NSF MCB-0718029, S-00000260, NSF IOS-1048216]
MicroRNAs (miRNAs) are 21-23 nucleotide (nt) non-coding RNAs that play a key role in regulating the expression of protein-coding genes at post-transcriptional levels in plants and animals. MiRNA genes, which serve as genetic buffers and regulators, are primarily located in the intergenic regions of the plant genome. The similar structure of a miRNA promoter to that of a protein-coding gene signifies the likely origin of miRNA genes from the latter. Imperfect inverted repeats, the hallmark of miRNA genes that defines the asymmetry of the stem-loop region of the miRNA precursors (pre-miRNAs), reflect the evolution of miRNA genes from the inverted duplication of their target genes over a long period of time. The deep conservation of most miRNAs and the presence of some of the non-conserved, species-specific miRNAs among various plant species demonstrate a continuous, but frequently an uneven evolutionary process of miRNA genes. Thus, duplication, inversion, mutation, amplification, and other types of genetic drift from protein-coding genes might be the primary events in the genesis and evolution of the miRNA genes. Subsequent co-evolution of the miRNA genes and their target genes ensures the maintenance and the fine-tuning nature of a dynamic gene regulatory network governed by miRNAs in plants. (C) 2010 Elsevier Ltd. All rights reserved.
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