期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 21, 期 7, 页码 683-690出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.03.002
关键词
Autophagy; Turnover; Metabolism; Starvation; Homeostasis
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Toray Science Foundation
- Takeda Science Foundation
Autophagy is a major intracellular degradation system in which the cytoplasmic contents are degraded in the lysosome. Its fundamental and evolutionarily conserved role is adaptation to starvation. Recent studies using autophagy-defective mutants of various organisms including mammals have indeed demonstrated the importance of autophagy during starvation; however, the exact mechanism underlying this beneficial effect remains unclear. In addition, it is now apparent that autophagy is also important for cellular homeostasis even under non-starvation conditions, and both non-selective and selective types of autophagy appear to be critical for this function. Here, we discuss the role of this catabolic pathway in recycling intracellular components, with particular reference to nutrient metabolism. (C) 2010 Elsevier Ltd. All rights reserved.
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