期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 21, 期 1, 页码 11-18出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2009.10.003
关键词
Mammary development; Breast cancer; Tumorigenesis; Stroma; Cancer-associated fibroblasts
资金
- American Cancer Society-New England Division
- National Center for Research Resources (NCRR) [K01-RR021858]
- Breast Cancer Research Foundation
- Department of Defense Breast Cancer Research Program [BC073866]
- NIH/NCI [R01CA125554]
- Raymond and Beverly Sackler Foundation Scholar
It is increasingly apparent that normal and malignant breast tissues require complex local and systemic stromal interactions for development and progression. During development, mammary cell fate specification and differentiation require highly regulated contextual signals derived from the stroma. Likewise, during breast carcinoma development, the tissue stroma can provide tumor suppressing and tumor-promoting environments that serve to regulate neoplastic growth of the epithelium. This review focuses on the role of the stroma as a mediator of normal mammary development, as well as a critical regulator of malignant conversion and progression in breast cancer. Recognition of the important role of the stroma during the progression of breast cancers leads to the possibility of new targets for treatment of the initial breast cancer lesion as well as prevention of recurrence. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据