期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 21, 期 9, 页码 866-873出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.08.003
关键词
Actin; Cell mechanics; Control system; Cytokinesis; Mechanosensing; Myosin II
资金
- NIH [GM066817, GM086704]
- American Cancer Society [RSG CCG-114122]
Cytokinesis is emerging as a control system defined by interacting biochemical and mechanical modules, which form a system of feedback loops. This integrated system accounts for the regulation and kinetics of cytokinesis furrowing and demonstrates that cytokinesis is a whole-cell process in which the global and equatorial cortices and cytoplasm are active players in the system. Though originally defined in Dictyostelium, features of the control system are recognizable in other organisms, suggesting a universal mechanism for cytokinesis regulation and contractility. (C) 2010 Elsevier Ltd. All rights reserved.
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