期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 21, 期 8, 页码 845-854出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.09.003
关键词
Satellite cell; Heterogeneity; Muscle; Regeneration; Lineage; Stem cell
资金
- Department of Veterans Affairs
- NIH [AG23806, AR056849, OD000392]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR056849] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG023806, R37AG023806] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD000392] Funding Source: NIH RePORTER
Satellite cells, the adult stem cells responsible for skeletal muscle regeneration, are defined by their location between the basal lamina and the fiber sarcolemma. Increasing evidence suggests that satellite cells represent a heterogeneous population of cells with distinct embryological origin and multiple levels of biochemical and functional diversity. This review focuses on the rich diversity of the satellite cell population based on studies across species. Ultimately, a more complete characterization of the heterogeneity of satellite cells will be essential to understand the functional significance in terms of muscle growth, homeostasis, tissue repair, and aging. Published by Elsevier Ltd.
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