期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 21, 期 2, 页码 148-155出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2009.06.006
关键词
Pericentriolar material; Cilium-pit; Endocytosis; Golgi-complex; Microtubule-based signaling
资金
- Canadian Institutes for Health [MOP-57674]
- Natural Sciences and Engineering Research Council of Canada [690481]
- CIHR
- Alberta Heritage Foundation
The centrosome is an organelle that acts as a microtubule-organizing center (MTOC) throughout the cell cycle. Within the centrosome are often two components that each have an ability to organize microtubule structures: the centriole that has the potential to function as a basal body and nucleate a cilium or a flagellum and a mass of protein material that in the presence of a centriole is commonly referred to as the pericentriolar material (PCM) that organizes cytoplasmic and spindle microtubule arrays. One characteristic of a large variety of cells is the ability to express a non-motile primary cilium. It is now appreciated that the function of the primary cilium is integral to a variety of essential cell functions and defects affecting this structure underlie a variety of human disease. While the function of the primary cilium and manner in which a basal body organizes a primary cilium has received extensive attention there is now a need to explore the inter-relationship between the PCM and the basal body/primary cilium. It is this latter topic that is the focus of this review where we show that the PCM is integrated with the centriole to form a coalition that is essential for both the expression and function of the primary cilium as well as the organization and function of the cellular environment that surrounds it. (C) 2009 Elsevier Ltd. All rights reserved.
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