期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 21, 期 3, 页码 290-299出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.01.017
关键词
Mitosis; Cytokinesis; Microtubule; Motor protein; Kinesin
资金
- National Institutes of Health [T32 CA080621, R01 GM072754]
- NATIONAL CANCER INSTITUTE [T32CA080621] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM072754] Funding Source: NIH RePORTER
In mammalian cultured cells the initiation of cytokinesis is regulated - both temporally and spatially - by the overlapping, anti-parallel microtubules of the spindle midzone. This region recruits several key central spindle components: PRC-1, polo-like kinase 1 (Plk-1), the centralspindlin complex, and the chromosome passenger complex (CPC), which together serve to stabilize the microtubule overlap, and also to coordinate the assembly of the cortical actin/myosin cytoskeleton necessary to physically cleave the cell in two. The localization of these crucial elements to the spindle midzone requires members of the kinesin superfamily of microtubule-based motor proteins. Here we focus on reviewing the role played by a variety of kinesins in both building and operating the spindle midzone machinery during cytokinesis. (C) 2010 Elsevier Ltd. All rights reserved.
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