期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 21, 期 6, 页码 609-615出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.02.010
关键词
N-Acetylglucosaminyltransferase I; Development; Caenorhabditis; Drosophila; Mouse
资金
- Canadian Institutes of Health Research (CIHR)
UDP-GlcNAc: alpha 3-d-mannoside beta 1,2-N-acetylglucosaminyltransferase I (GnTI, encoded by Mgat1) first appeared in evolution at about the same time as metazoa suggesting that GnTI-dependent glycans are essential for the development of multicellular organisms. This review describes the effects of mutations in the Mgat1 gene on the development of Caenorhabditis elegans, Drosophila melanogaster and mice. (C) 2010 Elsevier Ltd. All rights reserved.
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