期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 20, 期 4, 页码 456-463出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.11.010
关键词
Left-right asymmetry; Chirality; Cytoskeleton; Polarity; Review
资金
- NIH [R01-GM077425, R01-GM067227]
- American Heart Association Established Investigator [0740088N]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM077425, R01GM067227] Funding Source: NIH RePORTER
Embryonic left-right (LR) patterning is a fascinating aspect of embryogenesis. The field currently faces important questions about the origin of LR asymmetry, the mechanisms by which consistent asymmetry is imposed on the scale of the whole embryo, and the degree of conservation of early phases of LR patterning among model systems. Recent progress on planar cell polarity and cellular asymmetry in a variety of tissues and species provides a new perspective on the early phases of LR patterning. Despite the huge diversity in body-plans over which consistent LR asymmetry is imposed, and the apparent divergence in molecular pathways that underlie laterality, the data reveal conservation of physiological modules among phyla and a basic scheme of cellular chirality amplified by a planar cell polarity-like pathway over large cell fields. (C) 2008 Elsevier Ltd. All rights reserved.
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