期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 20, 期 7, 页码 770-779出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2009.03.011
关键词
Golgi structure; Golgi matrix; Golgin; GRASP; Tethering
资金
- MRC
- Wellcome Trust
- BBSRC
- MRC [G117/494] Funding Source: UKRI
- Medical Research Council [G117/494] Funding Source: researchfish
The GRASP and golgin families of proteins have emerged as key components of the Golgi apparatus, with major roles in both the structural organisation of this organelle and the trafficking that occurs there. Both types of protein participate in membrane tethering events that occur upstream of membrane fusion as well as contributing to the structural scaffold that defines Golgi architecture, referred to as the Golgi matrix. The importance of these proteins is highlighted by their targeting in mitosis, apoptosis, and pathogenic infections that cause dramatic structural and functional reorganisation of the Golgi apparatus. In this review we will discuss our current understanding of GRASP and golgin function, highlighting some of the common themes that have emerged as well as describing previously unsuspected roles for these proteins in various cellular processes. (C) 2009 Elsevier Ltd. All rights reserved.
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