期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 20, 期 9, 页码 1032-1040出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2009.06.001
关键词
RNA silencing; siRNA; Viral suppressors; DICER-LIKE proteins; ARGONAUTE
资金
- Texas AgriLife Research [TEX08387]
- NIH [1RO3-AI067384]
- USDA/CSREES-NRI-CGP [2006-35319-17211]
RNA silencing is a common strategy shared by eukaryotic organisms to regulate gene expression, and also operates as a defense mechanism against invasive nucleic acids such as viral transcripts. The silencing pathway is quite sophisticated in higher eukaryotes but the distinct steps and nature of effector complexes vary between and even within species. To counteract this defense mechanism viruses have evolved the ability to encode proteins that suppress silencing to protect their genomes from degradation. This review focuses on our current understanding of how individual components of the plant RNA silencing mechanism are directed against viruses, and how in turn virus-encoded suppressors target one or more key events in the silencing cascade. (C) 2009 Elsevier Ltd. All rights reserved.
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