期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 20, 期 4, 页码 378-386出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2009.02.005
关键词
Review; Forebrain; Cortex; Patterning; Regionalization
资金
- Nina Ireland
- Larry L. Hillblom Foundation
- Weston Havens Foundation
- NINDS [R01 NS34661]
- NIMH [R37MH49428]
- NIH [K02 MH074958, R01 DA017627, R01 MH066084, R01 MH077694]
Embryonic development of the mammalian forebrain is guided by signals from four patterning centers. The concerted actions of these signals transform the anterior neural plate and prosencephalon into discrete forebrain structures including the telencephalon (cerebral cortex and basal ganglia) and hypothalamus. In this review, we describe the signaling, transcriptional, and regulatory events that lead to induction of the prospective telencephalon, and that instruct regional development of distinct telencephalic areas along the rostrocaudal and dorsoventral axes. (C) 2009 Elsevier Ltd. All rights reserved.
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