期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 20, 期 2, 页码 153-163出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.09.006
关键词
ADAM; Disintegrin; Metalloproteases; Cell migration; Cell adhesion; Embryo
资金
- NIH [DE016289]
Cleavage of proteins inserted into the plasma membrane ( shedding) is an essential process controlling many biological functions including cell signaling, cell adhesion and migration as well as proliferation and differentiation. ADAM surface metalloproteases have been shown to play an essential role in these processes. Gene inactivation during embryonic development have provided evidence of the central role of ADAM proteins in nematodes, flies, frogs, birds and mammals. The relative contribution of four subfamilies of ADAM proteins to developmental processes is the focus of this review. (C) 2008 Elsevier Ltd. All rights reserved.
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