期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 19, 期 1, 页码 42-51出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2007.06.003
关键词
proteases; neural development; neuroinflammation; multiple sclerosis
Matrix metalloproteinases ( MMPs) are expressed in the developing, healthy adult and diseased CNS. We emphasize the regulation of neurogenesis and oligodendrogenesis by MMPs during CNS development, and highlight physiological roles of MMPs in the healthy adult CNS, such as in synaptic plasticity, learning and memory. Nonetheless, MMPs as the good guys go bad in neurological conditions, likely aided by the sudden and massive upregulation of several MMP members. We stress the necessity of drawing a fine balance in the treatment of neurological diseases, and we suggest that MMP inhibitors do have therapeutic potential early after CNS injury. (C) 2007 Elsevier Ltd. All rights reserved.
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