期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 19, 期 5, 页码 424-433出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.08.004
关键词
Osteoclast; Vesicular trafficking; Rab; Osteopetrosis; Lysosome
资金
- Arthritis Research UK [17285] Funding Source: Medline
- Versus Arthritis [17285] Funding Source: Medline
- Chief Scientist Office [CZB/4/495] Funding Source: Medline
Bone-resorbing osteoclasts are highly dependent on vesicular trafficking pathways that are regulated by Rab GTPases. In particular, polarised transport of acidic vesicles of the endocytic/lysosomal pathway is required for formation of the ruffled border, the resorptive organelle of the osteoclast. The breakdown products of resorption are then transported through the osteoclast by transcytosis, enabling their excretion. In this review, we summarise these trafficking routes, highlight the emerging evidence that the bone disease osteopetrosis results from defects in vesicular trafficking in osteoclasts, and outline the similarities between the endocytic/lysosomal compartment in osteoclasts and secretory lysosomes in other cell types. (C) 2008 Elsevier Ltd. All rights reserved.
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