期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 19, 期 6, 页码 494-501出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.07.005
关键词
Chlamydomonas; Flagellar length; Cilia; Intraflagellar transport; Signal transduction
Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intra. agellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet microtubules via IFT particles. Regulation of IFT activity therefore is pivotal in determining the length of a flagellum. Reviewed is our current understanding of the role of IFT and signal transduction pathways in the regulation of. agellar length. (c) 2008 Elsevier Ltd. All rights reserved.
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