期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 19, 期 3, 页码 263-270出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.01.005
关键词
morphogenesis; axis elongation; Drosophila; polarity; adhesion
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM079340] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM079340, R01 GM079340, R01 GM079340-02] Funding Source: Medline
The reorganization of multicellular populations to produce an elongated tissue structure is a conserved mechanism for shaping the body axis and several organ systems. In the Drosophila germband epithelium, this process is accompanied by the formation of a planar polarized network of junctional and cytoskeletal proteins in response to striped patterns of gene expression. Actomyosin cables and adherens junctions are dynamically remodeled during intercalation, providing the basis for polarized cell behavior. Quantitative analysis of cell behavior in living embryos reveals unexpected cell population dynamics that include the formation of multicellular rosette structures as well as local neighbor exchange. (C) 2008 Elsevier Ltd. All rights reserved.
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