期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 19, 期 3, 页码 224-233出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.01.003
关键词
yeast; fungi; morphogenesis; cell polarity; facilitated variation
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM057063] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM057063-10, R01 GM057063] Funding Source: Medline
- PHS HHS [R01-057063] Funding Source: Medline
Cellular morphogenesis is a complex process and molecular studies in the last few decades have amassed a large amount of information that is difficult to grasp in any completeness. Fungal systems, in particular the budding and fission yeasts, have been important players in unravelling the basic structural and regulatory elements involved in a wide array of cellular processes. In this article, we address the design principles underlying the various processes of yeast and fungal morphogenesis. We attempt to explain the apparent molecular complexity from the perspective of the evolutionary theory of facilitated variation. Following a summary of some of the most studied morphogenetic phenomena, we discuss, using recent examples, the underlying core processes and their associated weak regulatory linkages that bring about variation in morphogenetic phenotypes. (C) 2008 Elsevier Ltd. All rights reserved.
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