期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 19, 期 2, 页码 170-177出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2007.10.007
关键词
trophoblast; pregnancy; endometrium; interferon response; implantation
资金
- NICHD NIH HHS [R37 HD021896, HD 21896, R01 HD021896-21, R01 HD021896] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R37HD021896, R01HD021896] Funding Source: NIH RePORTER
Two-way communication between the conceptus and the mother during early pregnancy is essential if the pregnancy is to survive. In this review, our primary focus is on biochemical communication between the conceptus and mother in the ruminant ungulate species. We emphasize, in particular, the role played by interferon-tau (IFNT) in triggering maternal responses in cattle and sheep and how maternal factors intervene to up-regulate IFNT gene (IFNT) expression in trophoblast. However, we also consider the possibility that different signaling cytokines or the physical presence of trophoblast may induce a partial IFN response in endometrium of those species where there is no evidence for large scale trophoblast IFN production. Conceivably, disparate signaling mechanisms trigger common downstream events necessary to secure a successful pregnancy. (C) 2007 Elsevier Ltd. All rights reserved.
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