期刊
SEMINARS IN CANCER BIOLOGY
卷 53, 期 -, 页码 59-74出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2018.07.007
关键词
Breast cancer; Cancer stem cells; Notch; Wnt; Hedgehog; OSKM
类别
The current view is that breast cancer is a stem cell disease characterized by the existence of cancer cells with stem-like features and tumor-initiating potential. These cells are made responsible for tumor dissemination and metastasis. Common therapies by chemotherapeutic drugs fail to eradicate these cells and rather increase the pool of cancer stern cells in tumors, an effect that may increase the likelyhood of recurrence. Fifteen years after the first evidence for a small stem-like subpopulation playing a major role in breast cancer initiation has been published a large body of knowledge has been accumulated regarding the signaling cascades and proteins involved in maintaining sternness in breast cancer. Differences in the stern cell pool size and in mechanisms regulating sternness in the different breast cancer subtypes have emerged. Overall, this knowledge offers new approaches to intervene with breast cancer stern cell activity. New options are particularly needed for the treatment of triple-negative breast cancer subtype, which is particularly rich in cancer stem cells and is also the subtype for which specific therapies are still not available.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据