期刊
SEMINARS IN CANCER BIOLOGY
卷 25, 期 -, 页码 15-22出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2013.12.008
关键词
TGF-beta; Tumor microenvironment; Cancer-associated fibroblast; Metastasis; Stroma
类别
资金
- European Research Council [208488]
- Consolider programs (MICINN)
- Spanish Ministry of Science and Innovation
- Juan de la Cierva
- ICREA Funding Source: Custom
- European Research Council (ERC) [208488] Funding Source: European Research Council (ERC)
TGF-beta signaling is one of the major pathways controlling cell and tissue behavior not only in homeostasis but also in disease. During tumorigenesis TGF-beta orchestrated processes are key due to its dual role as tumor suppressor and tumor promoter. Important functions of this pathway have been described in a context-dependent manner both in epithelial cancer cells and in the tumor microenvironment during tumor progression. Carcinoma-associated fibroblasts (CAFs) are one of the most abundant stromal cell types in virtually all solid tumors. CAFs favor malignant progression by providing cancer cells with proliferative, migratory, survival and invasive capacities. A complex network of signaling pathways underlying their tumor-promoting properties is beginning to take shape. In this review, we examine current evidence on the emerging mechanisms involving TGF-beta in CAF-mediated cancer progression, and discuss their potential as therapeutic targets. (C) 2014 Elsevier Ltd. All rights reserved.
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