期刊
SEMINARS IN CANCER BIOLOGY
卷 28, 期 -, 页码 51-57出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2014.04.008
关键词
Exosome signaling; Myeloid derived suppressor cells; Cytokines; Chemokines
类别
资金
- Deutsche Krebshilfe [109745]
- DKFZ-NCT Tumorzentrum
- Cooperation Program in Cancer Research of the DKFZ
- Israel's Ministry of Science, Technology and Space (MOST) [CA157]
- Max-Eder Research Grant of the German Cancer Aid [109312]
The immune system of cancer patients is often suppressed. Accumulating evidence suggests that exosomes released from tumor cells may play an essential role in this process but the mechanisms are not fully understood. Here we review recent papers showing that exosomes trigger the release of cytokines/chemokines from immune cells. We suggest that this process will either result in the stimulation of anti-tumor immune reactions or in a systemic immunosuppression. The direction appears to be largely dependent on the duration of interactions between immune cells and exosomes leading to the accumulation of inflammatory factors, i.e. on the length of the exposure to these factors. We propose that a long-term interaction of the immune system with elevated levels of tumor exosomes contributes to the development of immunosuppression in cancer patients. (C) 2014 Elsevier Ltd. All rights reserved.
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