期刊
SEMINARS IN CANCER BIOLOGY
卷 23, 期 5, 页码 391-396出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2013.03.001
关键词
MHC class I; MHC class II; Phagocytosis; Exocytosis; T cell selection; CD4(+) T cells; CD8(+) T cells
类别
资金
- National Cancer Institute [R01CA108609]
- Sassella Foundation [10/02, 11/02, 12/02]
- Cancer Research Switzerland [KFS-02652-08- 2010]
- Association for International Cancer Research [11-0516]
- KFSPMS
- KFSPHLD of the University of Zurich
- Vontobel Foundation
- Baugarten Foundation
- EMDO Foundation
- Sobek Foundation
- Fondation Acteria
- Novartis
- Swiss National Science Foundation [310030_143979, CRSII3_136241]
Macroautophagy was originally discovered as a nutrient salvage pathway during starvation. By now it has not only become clear that degradation of cytoplasmic constituents via transport by autophagosomes to lysosomes can be used for innate and adaptive immunity, but that the core machinery assists antigen presentation to the immune system by a variety of vesicular transport pathways. All of these rely on the presentation of small protein waste fragments, which are generated by a variety of catabolic pathways, including macroautophagy, on major histocompatibility complex (MHC) molecules. In this review, we will point out how classical macroautophagy, as well as phagocytosis and exocytosis, which both benefit from the core autophagic machinery, assist in antigen presentation on MHC class I and II molecules to CD8+ and CD4+ T cells, respectively. Finally to high-light that macroautophagy is always intimately interconnected with cell death in addition to the various supported vesicular transport function, its role in lymphocyte, especially T cell, development and function will be discussed. From this body of work a picture is emerging that the core machinery of macroautophagy can be used for a variety of vesicular transport pathways and to modulate cell survival, besides its classical role in delivering intracellular material for lysosomal degradation. (C) 2013 Elsevier Ltd. All rights reserved.
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