期刊
SEMINARS IN CANCER BIOLOGY
卷 23, 期 5, 页码 329-336出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2013.05.004
关键词
Autophagy; Entosis; Phagocytosis; Cell death; Macrophage; Tumor; Immune
类别
资金
- National Cancer Institute [CA154649]
- Louis V. Gerstner, Jr. Young Investigators Fund
- Benjamin Friedman Research Fund
Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition. (C) 2013 Elsevier Ltd. All rights reserved.
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