期刊
SEMINARS IN CANCER BIOLOGY
卷 22, 期 3, 页码 216-225出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2012.02.006
关键词
S100 family; Metastasis; Microenvironment; Metastatic niche; Inflammation
类别
资金
- Danish Cancer Society
- European Union [HEALTH-F2-2008-201662]
Communication between cancer cells and stromal cells, often mediated by extracellular molecules in the tumor microenvironment, plays a central role in tumorigenesis and metastasis. The establishment of a pro-inflammatory milieu is increasingly recognized as an important consequence of these interactions. The family of S100 Ca2+-binding proteins has been implicated in many aspects of the interaction between cancer cells and stromal cells, and contributes to the formation of an inflammatory tumor microenvironment. Focusing on S100A4, S100A8 and S100A9, in this review we discuss the role these proteins play in primary tumors and in the development of metastases, in particular during the formation of pre-metastatic niches. (C) 2012 Elsevier Ltd. All rights reserved.
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