期刊
SEMINARS IN CANCER BIOLOGY
卷 22, 期 5-6, 页码 437-445出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2012.04.007
关键词
Cancer; Epithelial-to-mesenchymal transition; Metastasis; Translation; YB-1
类别
资金
- U.S. Department of Defense [W81XWH-07-1-0580]
- British Columbia Cancer Foundation through generous donations from Team Finn and other riders in the Ride to Conquer Cancer
Translational regulation is increasingly recognized as a critical mediator of gene expression. It endows cells with the ability to decide when a particular protein is expressed, thereby ensuring proper and prompt cellular responses to environmental cues. This ability to reprogram protein synthesis and to permit the translation of the respective regulatory messages is particularly important in complex changing environments, including embryonic development, wound healing and environmental stress. Not surprisingly, mistakes in this process can lead to cancer. This review will focus on the mechanisms of translational control operating in normal and cancer cells. We discuss the possibility that progression of primary epithelial tumors into a motile mesenchymal-like phenotype during the invasive phase of metastasis is driven, in part, by a switch from cap-dependent to cap-independent translation. (c) 2012 Elsevier Ltd. All rights reserved.
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