期刊
SEMINARS IN CANCER BIOLOGY
卷 22, 期 5-6, 页码 411-416出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2012.04.008
关键词
Neural crest; EMT; Development
类别
资金
- National Institutes of Health [R03DE022521, HD037105]
- California Institute of Technology
The epithelial-to-mesenchymal transition (EMT) is an important event converting compact and ordered epithelial cells into migratory mesenchymal cells. Given the molecular and cellular similarities between pathological and developmental EMTs, studying this event during neural crest development offers and excellent in vivo model for understanding the mechanisms underlying this process. Here, we review new and old insight into neural crest EMT in search of commonalities with cancer progression that might aid in the design of specific therapeutic prevention. (C) 2012 Elsevier Ltd. All rights reserved.
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