期刊
SEMINARS IN CANCER BIOLOGY
卷 22, 期 1, 页码 33-40出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2011.12.005
关键词
Inflammation; Macrophages; Cytokines; Chemokines; Tumor microenvironment
类别
Inflammatory cells and mediators are an essential component of the tumor microenvironment. Inflammatory circuits can differ considerably in different tumors in terms of cellular and cytokine networks and molecular drivers. However, macrophages are a common and fundamental component of cancer promoting inflammation. Drivers of macrophage functional orientation include tumor cells, cancer-associated fibroblasts. T cells and B cells. Dissection of the diversity of cancer-related inflammation is instrumental to the design of therapeutic approaches that target cancer-related inflammation. (C) 2011 Elsevier Ltd. All rights reserved.
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