期刊
SEMINARS IN CANCER BIOLOGY
卷 20, 期 2, 页码 71-76出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2009.12.001
关键词
Leukemia; Leukemia stem cells; Cancer stem cells
类别
资金
- National Health and Medical Research Council Australia, Australia/U.S
- Ful-bright Commission
- Haematology Society of Australia and New Zealand
- Royal Brisbane and Women's Hospital Foundation
- US National Institute of Health (NIH
- Bethesda, MD)
- Howard Hughes Medical Institute (Boston, MA)
- Leukemia & Lymphoma Society (White Plains, NY)
- Myeloproliferative Disorders Foundation (Chicago, IL)
Leukemia stem cells (LSC) reside within a hierarchy of malignant hematopoiesis and possess the ability to instigate, maintain and serially propagate leukemia in vivo, while retaining the capacity to differentiate into committed progeny that lack these properties. In most cases, LSC appear to share immunophenotypic characteristics with committed hematopoietic progenitors, however have pathologically enhanced self-renewal, mediated through the activation of certain cellular pathways. The presence of a LSC that solely possesses the ability to initiate and sustain leukemia has implications for the treatment of patients with this disease. In this review, we will discuss these issues as well as some of the recent controversies regarding LSC frequency and alternative theories of leukemogenesis. (C) 2009 Published by Elsevier Ltd.
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