期刊
SEMINARS IN CANCER BIOLOGY
卷 19, 期 1, 页码 50-56出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2008.12.001
关键词
Mitochondria; Fusion; Fission; Metabolism; Cancer
类别
资金
- Swiss National Science Foundation [3100A0-109419/1]
- Geneva Department of Education
Mitochondrial morphology is regulated by continuous fusion and fission events that are essential for maintaining a normal mitochondrial function. If the last years have witnessed major discoveries in the characterization of the fission and fusion machineries, little is known about the physiological role of mitochondrial dynamics. In this review we report the results showing evidences of relationships between mitochondrial dynamics and cellular metabolism, autophagy or apoptosis. We discuss how different mitochondrial alterations observed in cancer cells could be linked to unbalanced mitochondrial fission or fusion events and how this could impinge on key essential cellular processes, thereby contributing to tumorigenesis. (c) 2008 Elsevier Ltd. All rights reserved.
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