期刊
SEMINARS IN CANCER BIOLOGY
卷 19, 期 1, 页码 57-66出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2008.11.007
关键词
Cell death; Tumor; Mitochondria; Therapy; Warburg effect
类别
资金
- Swedish and Stockholm Cancer Societies
- Swedish Childhood Cancer Foundation
- The Swedish Research Council
- EC-FP-6 (Oncodeath and Chemores)
- EC-FP-7 (APO-SYS)
Heterogeneity of tumors dictates an individual approach to anticancer treatment. Despite their variability, almost all cancer cells demonstrate enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect, whereas mitochondrial activity in tumor cells is suppressed. Considering the key role of mitochondria in cell death, it appears that resistance of most tumors towards treatment can be, at least in part, explained by mitochondrial silencing in cancer cells. This review is devoted to the role of mitochondria in cell death, and describes how targeting of mitochondria can make tumor cells more susceptible to anticancer treatment. (c) 2008 Elsevier Ltd. All rights reserved.
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