期刊
SEMINARS IN CANCER BIOLOGY
卷 19, 期 1, 页码 25-31出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2008.11.010
关键词
Energy metabolism; Glycolysis; Oxygen consumption; Oxidative phosphorylation; Cancer
类别
资金
- United States Department of Veterans Affairs
- American Heart Association
- Hitchcock Foundation
- National Institutes of Health
The serine/threonine kinase Akt - also known as protein kinase B (PKB) - has emerged as one of the most frequently activated protein kinases in human cancer. In fact, most, if not all, tumors ultimately find a way to activate this important kinase. As such, Akt activation constitutes a hallmark of most cancer cells, and such ubiquity presumably connotes important roles in tumor genesis and/or progression. Likewise, the hypermetabolic nature of cancer cells and their increased reliance on aerobic glycolysis, as originally described by Otto Warburg and colleagues, are considered metabolic hallmarks of cancer cells. In this review, we address the specific contributions of Akt activation to the signature metabolic features of cancer cells, including the so-called Warburg effect. Published by Elsevier Ltd.
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