期刊
SEMINARS IN CANCER BIOLOGY
卷 18, 期 1, 页码 53-64出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2007.08.003
关键词
alpha-catenin; cancer; E-cadherin; cytoskeleton; adhesion
类别
资金
- NIGMS NIH HHS [R37 GM035527, R01 GM078270, R37 GM035527-25, R01 GM035527, GM 35527, R01 GM078270-03] Funding Source: Medline
- NINDS NIH HHS [R01 NS042735, R01 NS042735-04] Funding Source: Medline
The cadherin/catenin complex, comprised of E-cadherin; beta-catenin and alpha-catenin, is essential for initiating cell-cell adhesion, establishing cellular polarity and maintaining tissue organization. Disruption or loss of the cadherin/catenin complex is common in cancer. As the primary cell-cell adhesion protein in epithelial cells, E-cadherin has long been studied in cancer progression. Similarly, additional roles for beta-catenin in the Wnt signaling pathway has led to many studies of the role of beta-catenin in cancer. Alpha-catenin, in contrast, has received less attention. However, recent data demonstrate novel functions for alpha-catenin in regulating the actin cytoskeleton and cell-cell adhesion, which when perturbed could contribute to cancer progression. In this review, we use cancer data to evaluate molecular models of alpha-catenin function, from the canonical role of alpha-catenin in cell-cell adhesion to non-canonical roles identified following conditional alpha-catenin deletion. This analysis identifies alpha-catenin as a prognostic factor in cancer progression. (C) 2007 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据