期刊
SEMINARS IN CANCER BIOLOGY
卷 18, 期 2, 页码 103-110出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2008.01.008
关键词
RNA interference; microRNA; tumor suppressor; oncogene
类别
资金
- NCI NIH HHS [5R21CA116060, 5K01CA098176] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [K01CA098176, R21CA116060] Funding Source: NIH RePORTER
Cancer progression is mediated by overexpression of oncogenes and downregulation or loss of tumor suppressors. Proteins, which were traditionally categorized into these groups, have been recently joined by a species of RNA molecules known as microRNAs (miRNAs). miRNAs belong to a class of approximately 22-nt-long non-coding RNAs found in eukaryotes that hinder gene expression by inducing degradation or inhibiting translation of select mRNAs. A growing number of miRNAs have been implicated in promoting or suppressing tumorigenesis in a variety of tissues. The supporting evidence ranges from suggestive expression profiling data to direct functional validation using methods of forward and reverse genetics. We discuss the nature of published results, as well as the merits and pitfalls of various approaches aimed at identification of cancer-related miRNAs and their mRNA targets. (C) 2008 Elsevier Ltd. All rights reserved.
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