期刊
SCIENTIFIC REPORTS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep11353
关键词
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资金
- FAPESP [12/04818-5, 13/15144-8, 14/06090-4]
- CNPq
- viral genetic diversity program (VGDN)
- FAPESP project [10/19341-4]
- Institute Pasteur of Dakar
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/15144-8, 10/19341-4, 12/04818-5] Funding Source: FAPESP
Rift Valley Fever virus (RVFV) is a member of Bunyaviridae family that causes a febrile disease affecting mainly ruminants and occasionally humans in Africa, with symptoms that range from mid to severe. RVFV has a tri-segmented ssRNA genome that permits reassortment and could generate more virulent strains. In this study, we reveal the importance of reassortment for RVFV evolution using viral gene genealogy inference and phylodynamics. We uncovered seven events of reassortment that originated RVFV lineages with discordant origins among segments. Moreover, we also found that despite similar selection regimens, the three segments have distinct evolutionary dynamics; the longer segment L evolves at a significant lower rate. Episodes of discordance between population size estimates per segment also coincided with reassortment dating. Our results show that RVFV segments are decoupled enough to have distinct demographic histories and to evolve under different molecular rates.
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