期刊
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
卷 21, 期 1, 页码 65-69出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.seizure.2011.09.003
关键词
Epilepsia Partialis Continua; Focal cortical dysplasia; EEG/fMRI
资金
- UK's Department of Health's NIHR Biomedical Research Centres
We report on a 64 year-old woman presenting with Epilepsia Partialis Continua (EPC) affecting the left hand since the age of 24 without neurological deficit. Structural MRI showed a region of focal cortical dysplasia (FCD) over the right central gyrus and lesions in the mesial frontal and occipital cortex secondary to perinatal hypoxic injury. Ictal spike haemodynamic mapping using simultaneous EEG-fMRI revealed significant BOLD signal changes prominent in the region of FCD (larger cluster), occipital cortex (global statistical maximum), prefrontal cortex and cerebellum. The cluster over FCD was in good agreement with the result of EEG source analysis. Our findings provide an interesting illustration of the ability of EEG-fMRI to reveal epileptogenic networks confirming the intrinsic epileptogenic properties of dysplastic neurons. (C) 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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