期刊
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
卷 20, 期 9, 页码 727-730出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.seizure.2011.06.008
关键词
Myoclonic epilepsy; Epilepsy in infancy; Idiopathic epilepsy; Childhood absence epilepsy
资金
- University of Palermo
Benign myoclonic epilepsy in infancy (BMEI) is a rare syndrome included among idiopathic generalized epilepsies (ICE) and syndromes with age-related onset. Recently, it has been shown that a few patients with BMEI later had other epilepsy types mainly ICE but never childhood absence epilepsy (CAE). We report a patient who at 11 months of age showed isolated myoclonic jerks occurring several times a day. The ictal video-EEG and polygraphic recording revealed generalized discharge of spike-wave (SW) lasting 1-2 s associated with isolated bilateral synchronous jerk involving mainly the upper limbs controlled by valproic acid (VPA). At 6 years and 8 months the child developed a new electroclinical feature recognized as CAE. The ictal EEG disclosed a burst of rhythmic 3 Hz generalized SW. Our case is the first patient with BMEI reported in the literature who later developed a CAE. This finding suggests a common neurobiological and genetic link between different age-related epileptic phenotypes. (C) 2011 Published by Elsevier Ltd on behalf of British Epilepsy Association.
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