期刊
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
卷 20, 期 4, 页码 347-349出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.seizure.2011.01.001
关键词
Seizure; Ghrelin; PTZ
资金
- Neuroscience Research Centre of Tabriz University of Medical Sciences
Aim: Epilepsy is one of the most common neurologic problems worldwide. A relationship between epilepsy and hormones has been demonstrated. This study was designed to investigate the effect of seizure on blood ghrelin level. Methods: Twenty male Wistar rats were divided into two groups. The control group received saline and the pentylenetetrazole (PTZ) group received a single convulsive dose (50 mg/kg) of PTZ. Thirty minutes later blood samples were collected and acylated and unacylated ghrelin levels in the plasma were assayed. Results: Acylated or active form of ghrelin decreased significantly (p < 0.05) after a PTZ-induced seizure, but the reduction of unacylated and total blood ghrelin levels failed to reach statistical significance. Conclusion: These findings may reflect that PTZ-induced epilepsy decreases AG of plasma. (C) 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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