期刊
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
卷 18, 期 5, 页码 359-364出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.seizure.2009.01.004
关键词
Arachidonic acid; Modified Atkins diet; Ketogenic diet; Epilepsy; Antiepileptic drug; Polyunsaturated fatty acids; Status epilepticus
资金
- Conseil Regional Nord-Pas-de-Calais et CHRU de Lille
The ketogenic diet KD) and the modified Atkins diet are effective therapies for intractable epilepsy. We compared retrospectively the KD and modified Atkins diet in 27 children and also assessed serum long chain fatty acid profiles. After 3 months, using an intent-to-treat analysis, the KD was more successful, with >50% seizure reduction in 11/17 (65%) vs. 2/10 (20%) with the modified Atkins diet, p = 0.03. After 6 months, however, the difference was no longer significant: 7/17 (41%) vs. 2/10 (20%) (p = 0.24). We observed a preventive effect of both diets on the occurrence of status epilepticus. After 1 and 3 months of responders experienced a significant decrease in serum arachidonic acid concentration either diet, compared to non-responders. The KD and modified Atkins diet led to seizure reduction in this small pilot series, with slightly better results after 3 months with the KD, but not after 6 months. The decrease of serum arachidonic acid levels might be involved in the anticonvulsive effects of KD or modified Atkins diet. (C) 2009 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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