期刊
SCIENTIFIC REPORTS
卷 5, 期 -, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/srep14241
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资金
- University of Innsbruck
- Austrian Science Fund (FWF) [P25659-B19]
- Austrian Science Fund (FWF) [P25659] Funding Source: Austrian Science Fund (FWF)
Diabetes mellitus is characterized by disrupted glucose homeostasis due to loss or dysfunction of insulin-producing beta cells. In this work, we characterize pancreatic islet development and function in zebrafish mutant for pdx1, a gene which in humans is linked to genetic forms of diabetes and is associated with increased susceptibility to Type 2 diabetes. Pdx1 mutant zebrafish have the key diabetic features of reduced beta cells, decreased insulin and elevated glucose. The hyperglycemia responds to pharmacologic anti-diabetic treatment and, as often seen in mammalian diabetes models, beta cells of pdx1 mutants show sensitivity to nutrient overload. This unique genetic model of diabetes provides a new tool for elucidating the mechanisms behind hyperglycemic pathologies and will allow the testing of novel therapeutic interventions in a model organism that is amenable to high-throughput approaches.
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