期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 6, 期 235, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3008249
关键词
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资金
- National Health and Medical Research Council Early Career Fellowship (Australia)
- Haematology Society of Australia
- New Zealand New Investigator Award
- MRC/Oxford University Clinical Academic Graduate School/Academy of Medical Sciences
- Wellcome Trust
- INSTAPA project
- European Union's Seventh Framework Programme [211484]
- MRC UK
- Netherlands Organisation for Scientific Research/WOTRO [W93-413, WAO93-441]
- United Nations International Children's Emergency Fund
- Cornelis Visser Foundation
- Wageningen University (Interdisciplinary Research and Education Fund)
- Wellcome Trust [094780]
- MRC UK [MC-A760-5QX00]
- NIHR Oxford Biomedical Research Centre
- Bill and Melinda Gates Foundation (Hepcidin and Iron in Global Health) [OPP1055865]
- Bill and Melinda Gates Foundation [OPP1055865] Funding Source: Bill and Melinda Gates Foundation
- Academy of Medical Sciences (AMS) [AMS-SGCL5-Atkinson] Funding Source: researchfish
- Medical Research Council [G0901149, MC_U123292699, MC_UU_12010/10] Funding Source: researchfish
- MRC [MC_UU_12010/10, MC_U123292699, G0901149] Funding Source: UKRI
Childhood anemia is a major global health problem resulting from multiple causes. Iron supplementation addresses iron deficiency anemia but is undesirable for other types of anemia and may exacerbate infections. The peptide hormone hepcidin governs iron absorption; hepcidin transcription is mediated by iron, inflammation, and erythropoietic signals. However, the behavior of hepcidin in populations where anemia is prevalent is not well established. We show that hepcidin measurements in 1313 African children from The Gambia and Tanzania (samples taken in 2001 and 2008, respectively) could be used to identify iron deficiency anemia. A retrospective secondary analysis of published data from 25 Gambian children with either postmalarial or nonmalarial anemia demonstrated that hepcidin measurements identified individuals who incorporated >20% oral iron into their erythrocytes. Modeling showed that this sensitivity of hepcidin expression at the population level could potentially enable simple groupings of individuals with anemia into iron-responsive and non-iron-responsive subtypes and hence could guide iron supplementation for those who would most benefit.
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