4.8 Article

RNAi Therapies: Drugging the Undruggable

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SCIENCE TRANSLATIONAL MEDICINE
卷 6, 期 240, 页码 -

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AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3008362

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资金

  1. Ovarian Cancer Research Fund, Foundation for Women's Cancer
  2. Cancer Prevention and Research Institute of Texas [RP101502, RP101489, RP120214, RP110595]
  3. National Institutes of Health [U54CA151668, CA109298, P50 CA083639, P50 CA098258, RC2GM09259, CA177909, UH2 TR000943, CA16672, U54 CA096300]
  4. Betty Anne Asche Murray Distinguished Professorship

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RNA interference (RNAi) therapy is a rapidly emerging platform for personalized cancer treatment. Recent advances in small interfering RNA delivery and target selection provide unprecedented opportunities for clinical translation. Here, we discuss these advances and present strategies for making RNAi-based therapy a viable part of cancer management.

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