期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 6, 期 265, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3009337
关键词
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资金
- DFG (Deutsche Forschungsgemeinschaft) German Research Foundation [SFB829]
- NRW/EU Ziel 2-Programm Europaischer Fond fur regionale Entwicklung (EFRE)
- Wellcome Trust
- Medical Research Council
- Cancer Research UK
- British Heart Foundation and Biotechnology and Biological Sciences Research Council
- NIH [5R01NR013881, 9R01DK098055]
- British Heart Foundation [PG/12/13/29434] Funding Source: researchfish
- Medical Research Council [MR/J002577/1, G0901822] Funding Source: researchfish
- Wellcome Trust [097791/Z/11/Z] Funding Source: researchfish
- MRC [G0901822, MR/J002577/1] Funding Source: UKRI
The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body's natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.
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