期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 6, 期 242, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3008825
关键词
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资金
- Production Assistance for Cellular Therapies program (National Heart, Lung, and Blood Institute) [HHSN268201000007C]
- Clinical Research Center
- Dan L. Duncan Institute for Clinical and Translational Research
- Dan L. Duncan Cancer Center [P30CA125123]
- Leukemia and Lymphoma Society
- American Society for Blood and Marrow Transplantation
- HHV-6 Foundation
- Dan L. Duncan Chair
- Fayez Sarofim Chair
- NIH-National Cancer Institute [P01 CA094237, P50 CA126752]
It remains difficult to treat the multiplicity of distinct viral infections that afflict immunocompromised patients. Adoptive transfer of virus-specific T cells (VSTs) can be safe and effective, but such cells have been complex to prepare and limited in antiviral range. We now demonstrate the feasibility and clinical utility of rapidly generated single-culture VSTs that recognize 12 immunogenic antigens from five viruses (Epstein-Barr virus, adenovirus, cytomegalovirus, BK virus, and human herpesvirus 6) that frequently cause disease in immunocompromised patients. When administered to 11 recipients of allogeneic transplants, 8 of whom had up to four active infections with the targeted viruses, these VSTs proved safe in all subjects and produced an overall 94% virological and clinical response rate that was sustained long-term.
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